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A polyketide with antibacterial and anticancer activities
Rubiginone D2 is a polyketide that has been found in Streptomyces that has antibacterial and anticancer activities.1 It is active against S. aureus and E. coli, but not B. subtilis, in agar diffusion assays when used at a concentration of 64 µg/disc. Rubiginone D2 inhibits growth of HM02, KATO III, HepG2, and MCF-7 cancer cells (GI50s = 0.1, 0.7, <0.1, and 7.5 µmol/L).
1.Puder, C., and Zeeck, A.New biologically active rubiginones from Streptomyces spJ. Antibiot. (Tokyo)53(4)329-336(2000)
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