An internal standard for the quantification of 15-HETE
(±)15-HETE-d8 is intended for use as an internal standard for the quantification of 15-HETE by GC- or LC-MS. (±)15-HETE and 15(S)-HETE are formed via non-enzymatic and 15-lipoxygenase-mediated oxidation of arachidonic acid , respectively.1,2 15(R)-HETE is formed by aspirin-acetylated COX-2-mediated oxidation of arachidonic acid.3
1.Powell, W.S., and Rokach, J.Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidBiochim. Biophys. Acta1851(4)340-355(2014) 2.Derogis, P.B.M.C., Chaves-Filho, A.B., and Miyamoto, S.Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometryBioactive lipids in health and disease21-38(2019) 3.Lecomte, M., Laneuville, O., Ji, C., et al.Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirinJ. Biol. Chem.269(18)13207-13215(1994)
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