A polyketide with fungicidal and plant growth inhibitory properties
7-dechloro Griseofulvin is a polyketide and derivative of griseofulvin that has been found in Penicillium and has fungicidal and plant growth inhibitory properties.1,2,3 It is active against the plant pathogenic fungi B. cinerea, C. orbiculare, R. solani, and S. sclerotiorum with EC50 values of 40, 81.7, 43.9, and 28.5 µg/ml, respectively.2 7-dechloro Griseofulvin (1-300 mg/L) inhibits hypocotyl and root growth of lettuce seedlings.3
1.Zhang, H.-M., Ju, C.-X., Li, G., et al.Dimeric 1,4-benzoquinone derivatives with cytotoxic activities from the marine-derived fungus Penicillium sp. L129Mar. Drugs17(7)383(2019) 2.Zhao, J.H., Zhang, Y.L., Wang, L.W., et al.Bioactive secondary metabolites from Nigrospora sp. LLGLM003, an endophytic fungus of the medicinal plant Moringa oleifera Lam.World J. Microbiol. Biotechnol.28(5)2107-2112(2012) 3.Kimura, Y., Shiojima, K., Nakajima, H., et al.Structure and biological activity of plant growth regulators produced by Penicillium sp. No. 31fBiosci. Biotechnol. Biochem.56(7)1138-1139(1992)
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