An internal standard for the quantification of norethindrone
Norethindrone-d6 is intended for use as an internal standard for the quantification of norethindrone by GC- or LC-MS. Norethindrone is a synthetic progestin.1 In vivo, norethindrone (0.5 mg/animal per day) inhibits the estrous cycle in female mice. It induces tumor progression and metastasis in a BT474 breast cancer mouse xenograft model.2 Formulations containing norethindrone have been used as oral contraceptives.
1.Bruce, H.M.Preliminary note on the effect of 19-norethisterone on mating behavior and fertility in the mouseProc. Soc. Study Fertility10158-165(1958) 2.Liang, Y., Benakanakere, I., Besch-Williford, C., et al.Synthetic progestins induce growth and metastasis of BT-474 human breast cancer xenografts in nude miceMenopause17(5)1040-1047(2010)
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