A bacterial metabolite with diverse biological activities
Carbazomycin D is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2 It is active against the fungi T. asteroides and T. mentagrophytes (MIC = 100 µg/ml for both) and the bacterium M. tuberculosis (IC50 = 25 µg/ml). Carbazomycin D is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 21.3, 33.2, 12.9, and 34.3 µg/ml, respectively).2
1.Naid, T., Kitahara, T., Kaneda, M., et al.Carbazomycins C, D, E and F, minor components of the carbazomycin complexJ. Antibiot. (Tokyo)40(2)157-164(1987) 2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011)
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