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- NG,NG-dimethyl-L-Arginine-d6 (hydrochloride)
NG,NG-dimethyl-L-Arginine-d6 (hydrochloride)
An internal standard for the quantification of NG,NG-dimethyl-L-arginine
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包装价格促销价数量
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1mg￥2037.001630.00- +
- 货号: ajcx24690
- CAS: 1313730-20-9
- 别名: NG,NG-Dimethylarginine-d<sub＞6</sub＞ dihydrochloride
- 分子式: C8H12D6N4O2?2HCl
- 分子量: 281.2
- 纯度: ＞98%
- 溶解度: DMF: 5 mg/ml,DMSO: 3 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): freely soluble
- 储存: -20°C; protect from light
- 库存: 现货
Background
NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS).1,2 It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2).1 ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet.2 ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.1,3,4
1.Sydow, K., and Münzel, T.ADMA and oxidative stressAtheroscler. Suppl.4(4)41-51(2003) 2.Jin, J.S., and D'Alecy, L.G.Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitorJ. Cardiovasc. Pharmacol.28(3)439-446(1996) 3.Vallance, P., Leone, A., Calver, A., et al.Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failureLancet339(8793)572-575(1992) 4.Matsuoka, H., Itoh, S., Kimoto, M., et al.Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertensionHypertension29(1 Pt 2)242-247(1997)
