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  • Arbutin-d4
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Arbutin-d4

An internal standard for the quantification of arbutin

原价
¥6137-6137
价格
4910-4910
Arbutin-d4的二维码

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  • 货号: ajcx24696
  • CAS: N/A
  • 别名: β-Arbutin-d4
  • 分子式: C12H12D4O7
  • 分子量: 276.3
  • 纯度: >98%
  • 溶解度: Water: soluble
  • 储存: -20°C
  • 库存: 现货

Background

Arbutin-d4 is intended for use as an internal standard for the quantification of arbutin by GC- or LC-MS. Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties.1,2 It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).3 Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM.2 In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum.4 Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.



1.Seo, D.-H., Jung, J.-H., Lee, J.-E., et al.Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivativesAppl. Microbiol. Biotechnol.95(6)1417-1425(2012) 2.Takebayashi, J., Ishii, R., Chen, J., et al.Reassessment of antioxidant activity of arbutin: Multifaceted evaluation using five antioxidant assay systemsFree Radic. Res.44(4)473-478(2010) 3.Maeda, K., and Fukuda, M.Arbutin: Mechanism of its depigmenting action in human melanocyte cultureJ. Pharmacol. Exp. Ther.276(2)765-769(1996) 4.Ye, J., Guan, M., Lu, Y., et al.Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathwayPulm. Pharmacol. Ther.5453-59(2019)

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