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- 5α-Androst-16-en-3α-ol
5α-Androst-16-en-3α-ol
A pheromone with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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10mg￥937.00750.00- +
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50mg￥3687.002950.00- +
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100mg￥5537.004430.00- +
- 货号: ajcx24700
- CAS: 1153-51-1
- 别名: (3α,5α)-16-烯-3-甾醇
- 分子式: C19H30O
- 分子量: 274.4
- 纯度: ＞98%
- 溶解度: DMF: 20 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml
- 储存: -20°C
- 库存: 现货
Background
5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2 It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM).2 5α-Androst-16-en-3α-ol (0.1-1 µM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors. In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5α-Androst-16-en-3α-ol protects against seizures induced by pentylenetetrazole or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively).
1.Brooksbank, B.W., Brown, R., and Gustafsson, J.A.The detection of 5α-androst-16-en-3α-ol in human male axillary sweatExperientia30(8)864-865(1974) 2.Kaminski, R.M., Marini, H., Ortinski, P.I., et al.The pheromone androstenol (5α-androst-16-en-3α-ol) is a neurosteroid positive modulator of GABAA receptorsJ. Pharmacol. Exp. Ther.317(2)694-703(2006)
