APHS

A COX inhibitor

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库存: 现货

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包装

价格

促销价

数量
1mg

￥150.00

120.00

- +
5mg

￥737.00

590.00

- +
10mg

￥1312.00

1050.00

- +
50mg

￥5737.00

4590.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx24726
CAS: 209125-28-0
别名:
分子式: C15H18O2S
分子量: 262.4
纯度: ＞98%
溶解度: DMF: ＞14.3 mg/ml,DMSO: ＞11.1 mg/ml,Ethanol: ＞12.5 mg/ml,PBS pH 7.2: <20 μg/ml
储存: -20°C
库存: 现货

Background

APHS is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and -2, with IC₅₀ values of 17 and 0.8 µM for human recombinant COX-1 and -2, respectively.¹ APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1. APHS acetylates COX-1 at Ser⁵³⁰ and COX-2 at Ser⁵¹⁶ resulting in irreversible enzyme inhibition.¹

1.Kalgutkar, A.S., Crews, B.C., Rowlinson, S.W., et al.Aspirin-like molecules that covalently inactivate cyclooxygenase-2Science2801268-1270(1998)

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信号通路

生命科学

有机化学

无机化学

材料科学

APHS

APHS详情

Background

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