A bacterial metabolite with diverse biological activities
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Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2 It is active against S. aureus, T. asteroides, and T. mentagrophytes (MIC = 12.5 µg/ml for all), as well as the plant pathogenic fungus P. oryzae (MIC = 25 µg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 µg/ml, respectively).2
1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological propertiesJ Antibiot. (Tokyo)33(7)683-689(1980) 2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011)
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