BRD9876

An Eg5 inhibitor

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库存: 现货

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数量
1g

￥1125.00

900.00

- +
5g

￥5275.00

4220.00

- +

已选 0 种 0 瓶

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货号: ajcx24808
CAS: 32703-82-5
别名: 6-叔丁基-2,3-二氰基萘
分子式: C16H14N2
分子量: 234.3
纯度: >98%
溶解度: Chloroform: 10 mg/ml,DMF: 1 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml
储存: -20°C
库存: 现货

Background

BRD9876 is an inhibitor of the kinesin spindle protein Eg5.¹ It arrests Eg5-mediated microtubule gliding, as well as inhibits Eg5 ATPase activity in the presence of microtubules, in cell-free assays. BRD9876 is cytotoxic to MM.1S stroma-independent multiple myeloma cells (IC₅₀ = 2.2 µM). It induces cell cycle arrest at the G₂/M phase in MM.1S cells when used at a concentration of 10 µM.

1.Chattopadhyay, S., Stewart, A.L., Mukherjee, S., et al.Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitorsCell Rep.10(5)755-770(2015)