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  2. Microtubule/Tubulin
  3. BRD9876
  • BRD9876
BRD9876的可视化放大

BRD9876

An Eg5 inhibitor

原价
￥1125-5275
价格
￥ 900-4220
BRD9876的二维码

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  • 库存: 现货
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  • 货号: ajcx24808
  • CAS: 32703-82-5
  • 别名: 6-叔丁基-2,3-二氰基萘
  • 分子式: C16H14N2
  • 分子量: 234.3
  • 纯度: >98%
  • 溶解度: Chloroform: 10 mg/ml,DMF: 1 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml
  • 储存: -20°C
  • 库存: 现货

Background

BRD9876 is an inhibitor of the kinesin spindle protein Eg5.1 It arrests Eg5-mediated microtubule gliding, as well as inhibits Eg5 ATPase activity in the presence of microtubules, in cell-free assays. BRD9876 is cytotoxic to MM.1S stroma-independent multiple myeloma cells (IC50 = 2.2 µM). It induces cell cycle arrest at the G2/M phase in MM.1S cells when used at a concentration of 10 µM.



1.Chattopadhyay, S., Stewart, A.L., Mukherjee, S., et al.Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitorsCell Rep.10(5)755-770(2015)

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