An internal standard for the quantification of guaifenesin
Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant.1 It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner.2 Guaifenesin (50 mg/kg, p.o.) increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing guaifenesin have been used as expectorants in the treatment of the common cold and chronic bronchitis.
1.Seagrave, J., Albrecht, H.H., Hill, D.B., et al.Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cellsRespir. Res.13(1)98(2012) 2.Seagrave, J., Albrecht, H., Park, Y.S., et al.Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cellsExp. Lung Res.37(10)606-614(2011) 3.Kagan, L., Lavy, E., and Hoffman, A.Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat modelPulm. Pharmacol. Ther.22(3)260-265(2009)
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