A tobacco-specific nitrosamine
(R,S)-N-Nitrosoanatabine (N-NAT) is a tobacco-specific nitrosamine (TSNA) that has been found in tobacco, tobacco products, and electronic cigarettes.1,2 The (S) enantiomer comprises approximately 80% of the N-NAT found in commercial and research cigarettes and smokeless tobacco.3 Unlike other TSNAs, N-NAT is not carcinogenic in rats when administered at doses of 1, 3, and 9 mmol/kg.1
1.Hoffmann, D., Rivenson, A., Amin, S., et al.Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 ratsJ. Cancer Res. Clin. Oncol.108(1)81-86(1984) 2.Kim, H.-J., and Shin, H.-S.Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography-tandem mass spectrometryJ. Chromatogr. A129148-55(2013) 3.Carmella, S.G., McIntee, E.J., Chen, M., et al.Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobaccoCarcinogenesis21(4)839-843(2000)
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