Ethionamide-d3

An internal standard for the quantification of ethionamide

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500ug

￥2662.00

2130.00

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1mg

￥5025.00

4020.00

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5mg

￥17062.00

13650.00

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Background

Ethionamide-d₃ is intended for use as an internal standard for the quantification of ethionamide by GC- or LC-MS. Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 µg/ml).^1,2 It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis.¹ Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.

1.Laborde, J., Deraeve, C., and Bernardes-Génisson, V.Update of antitubercular prodrugs from a molecular perspective: Mechanisms of action, bioactivation pathways, and associated resistanceChemMedChem12(20)1657-1676(2017) 2.Heifets, L.B., Lindholm-Levy, P.J., and Flory, M.Comparison of bacteriostatic and bactericidal activity of isoniazid and ethionamide against Mycobacterium avium and Mycobacterium tuberculosisAm. Rev. Respir. Dis.143(2)268-270(1991)