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- RSV (Respiratory syncytial virus)
- Sekikaic Acid
Sekikaic Acid
A lichen metabolite with diverse biological activities
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包装价格促销价数量
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1mg￥3875.003100.00- +
- 货号: ajcx24934
- CAS: 607-11-4
- 别名:
- 分子式: C22H26O8
- 分子量: 418.4
- 纯度: ＞98%
- 溶解度: DMSO: soluble,Ethanol: soluble,Methanol: soluble
- 储存: -20°C
- 库存: 现货
Background
Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities.1,2,3 It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM.1 Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 µg/ml).2 It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 µM).3
1.Thadhani, V.M., Choudhary, M.I., Ali, S., et al.Antioxidant activity of some lichen metabolitesNat. Prod. Res.25(19)1827-1837(2011) 2.Lai, D., Odimegwu, D.C., Esimone, C., et al.Phenolic compounds with in vitro activity against respiratory syncytial virus from the Nigerian lichen Ramalina farinaceaPlanta Med.79(15)1440-1446(2013) 3.Majmudar, C.Y., H?jfeldt, J.W., Arevang, C.J., et al.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300Angew. Chem. Int. Ed. Engl.51(45)11258-11262(2012)
