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- Taurodeoxycholic Acid (sodium salt hydrate)
Taurodeoxycholic Acid (sodium salt hydrate)
A taurine-conjugated form of deoxycholic acid
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包装价格促销价数量
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1g￥712.00570.00- +
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5g￥1812.001450.00- +
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25g￥7187.005750.00- +
- 货号: ajcx24942
- CAS: 207737-97-1
- 别名: 牛磺脱氧胆酸钠水合物
- 分子式: C26H44NO6S·Na [XH2O]
- 分子量: 521.7
- 纯度: ＞98%
- 溶解度: DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 3 mg/ml
- 储存: -20°C
- 库存: 现货
Background
Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid .1 Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.2 Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1
1.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 2.Hendrick, S.M., Mroz, M.S., Greene, C.M., et al.Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cellsAm. J. Physiol. Lung. Cell. Mol. Physiol.307(5)L407-L418(2014)
