- 首页
- HDAC (Histone deacetylases)
- 9-hydroxy Stearic Acid
9-hydroxy Stearic Acid
A hydroxy fatty acid
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥800.00640.00- +
-
5mg￥3600.002880.00- +
-
10mg￥6400.005120.00- +
-
25mg￥13887.0011110.00- +
- 货号: ajcx24958
- CAS: 3384-24-5
- 别名: 9-羟基十八酸
- 分子式: C18H36O3
- 分子量: 300.5
- 纯度: ＞98%
- 溶解度: Chloroform: soluble
- 储存: -20°C
- 库存: 现货
Background
9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA .1,2 It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 µM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates.3 It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 µM.1
1.Calonghi, N., Cappadone, C., Pagnotta, E., et al.9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cellsBiochem. Biophys. Res. Commun.314(1)138-142(2004) 2.Kolar, M.J., Kamat, S.S., Parsons, W.H., et al.Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipaseBiochemistry55(33)4636-4641(2016) 3.Calonghi, N., Cappadone, C., Pagnotta, E., et al.Histone deacetylase 1: A target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancerJ. Lipid Res.46(8)1596-1603(2005)
