An internal standard for the quantification of glycohyocholic acid
Glycohyocholic Acid-d4 (GHCA-d4) is intended for use as an internal standard for the quantification of GHCA by GC- or LC-MS. GHCA is a glycine-conjugated form of the primary bile acid hyocholic acid .1 GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.2 Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.3
1.Guo, L., Milburn, M.V., Ryals, J.A., et al.Plasma metabolomic profiles enhance precision medicine for volunteers of normal healthProc. Nat. Acad. Sci. USA112(35)E4901-E4910(2015) 2.Fitian, A.I., Nelson, D.R., Liu, C., et al.Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MSLiver Int.34(9)1428-1444(2014) 3.Yu, H., Ni, Y., Bao, Y., et al.Chenodeoxycholic acid as a potential prognostic marker for Roux-en-Y gastric bypass in Chinese obese patientsJ. Clin. Endocrinol. Metab.100(11)4222-4230(2015)
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