Glycohyocholic Acid-d4

An internal standard for the quantification of glycohyocholic acid

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1mg

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货号: ajcx24994
CAS: N/A
别名: Glycine hyocholate-d4
分子式: C26H39D4NO6
分子量: 469.7
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
储存: -20°C
库存: 现货

Background

Glycohyocholic Acid-d₄ (GHCA-d₄) is intended for use as an internal standard for the quantification of GHCA by GC- or LC-MS. GHCA is a glycine-conjugated form of the primary bile acid hyocholic acid .¹ GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.² Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.³

1.Guo, L., Milburn, M.V., Ryals, J.A., et al.Plasma metabolomic profiles enhance precision medicine for volunteers of normal healthProc. Nat. Acad. Sci. USA112(35)E4901-E4910(2015) 2.Fitian, A.I., Nelson, D.R., Liu, C., et al.Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MSLiver Int.34(9)1428-1444(2014) 3.Yu, H., Ni, Y., Bao, Y., et al.Chenodeoxycholic acid as a potential prognostic marker for Roux-en-Y gastric bypass in Chinese obese patientsJ. Clin. Endocrinol. Metab.100(11)4222-4230(2015)