An internal standard for the quantification of β-muricholic acid
β-Muricholic acid-d4 (β-MCA-d4) is intended for use as an internal standard for the quantification of β-muricholic acid by GC- or LC-MS. β-MCA is a murine-specific primary bile acid.1,2 Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.3 Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.4
1.Eyssen, H.J., Parmentier, G.G., and Mertens, J.A.Sulfate bile acids in germ-free and conventional miceEur. J. Biochem.66(3)507-514(1976) 2.Wahlstr?m, A., Sayin, S.I., Marschall, H.-I., et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolismCell Metab.24(1)41-50(2016) 3.Fujino, Y., Nakayama, K., Yoshimura, K., et al.Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acidJpn. J. Pharmacol.46(4)421-423(1988) 4.Wang, D.Q.-H., and Tazuma, S.Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J miceJ. Lipid. Res.43(11)1960-1968(2002)
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