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- Acetyl-CoA carboxylase (ACC)
- Tauro-β-muricholic Acid-d4 (sodium salt)
Tauro-β-muricholic Acid-d4 (sodium salt)
tauro-β-muricholic acid 定量的内标
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包装价格促销价数量
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1mg￥10750.008600.00- +
- 货号: ajcx25006
- CAS: N/A
- 别名: Tauro-β-muricholate-d4, TβMCA-d4
- 分子式: C26H40D4NO7S·Na
- 分子量: 541.7
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
- 储存: -20°C
- 库存: 现货
Background
Tauro-β-muricholic acid-d4 (TβMCA-d4) is intended for use as an internal standard for the quantification of TβMCA by GC- or LC-MS. TβMCA is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid .1 TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.1,2 TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.3
1.Sayin, S.I., Wahlstr?m, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013) 2.Wahlstr?m, A., Kovatcheva-Datchary, P., St?hlman, M., et al.Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiotaJ. Lipid. Res.58(2)412-419(2017) 3.Qi, Y., Jiang, C., Cheng, J., et al.Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in miceBiochim. Biophys. Acta.1851(1)19-29(2015)
