CXCR3 Antagonist 6c

A CXCR3 antagonist

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库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥800.00

640.00

- +
5mg

￥3600.00

2880.00

- +
10mg

￥6000.00

4800.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).¹ It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC₅₀ = 0.06 µM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 µM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC₅₀ = ~100 nM).

1.Cole, A.G., Stroke, I.L., Brescia, M.-R., et al.Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonistsBioorg. Med. Chem. Lett.16(1)200-203(2006)