1(R)-(Trifluoromethyl)oleyl alcohol

An oleic acid analog

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库存: 现货

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500ug

￥2037.00

1630.00

- +
1mg

￥3862.00

3090.00

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5mg

￥18112.00

14490.00

- +

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Background

1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .¹ It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 µM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 µM) reduces lipid peroxidation induced by FXN siRNA knockdown in NBT human myoblasts.

1.Cotticelli, M.G., Forestieri, R., Xia, S., et al.Identification of a novel oleic acid analog with protective effects in multiple cellular models of Friedreich ataxiaACS Chem. Neurosci.11(17)2535-2542(2020)