A siderophore with anticancer activity
Bisucaberin is a siderophore and bacterial metabolite that has been found in A. haloplanktis and has anticancer activity.1,2 It inhibits the growth of L1210 and 1MC carcinoma cells (IC50s = 9.7 and 12.7 µM, respectively) and sensitizes fibrosarcoma 1023 cells to macrophage-mediated cytolysis.
1.Hou, Z., Raymond, K.N., O’Sullivan, B., et al.A preorganized siderophore: Thermodynamic and structural characterization of alcaligin and bisucaberin, microbial macrocyclic dihydroxamate chelating agentsInorg. Chem.37(26)6630-6637(1998) 2.Kameyama, T., Takahashi, A., Kurasawa, S., et al.Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. I. Taxonomy of the producing organism, isolation and biological propertiesJ. Antibiot. (Tokyo)40(12)1664-1670(1987)
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