A bacterial metabolite with diverse biological activities
Benastatin C is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities.1,2 It inhibits glutathione S-transferase (GST; IC50 = 24 µg/ml for the rat liver enzyme).2 Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50 = 10 µg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner.
1.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007) 2.Aoyama, T., Kojima, F., Yamazaki, T., et al.Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activitiesJ. Antibiot. (Tokyo)46(5)712-718(1993)
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