A bacterial metabolite and an inhibitor of dopamine β-hydroxylase
Dopastin is a bacterial metabolite that has been found in Pseudomonas and an inhibitor of dopamine β-hydroxylase (Ki = 4.7 µM).1,2 In vivo, dopastin (20 mg/kg) reduces mean systolic blood pressure in spontaneously hypertensive rats. Dopastin also inhibits the germination of barley seeds (IC50 = 47 µM).2
1.Iinuma, H., Takeuchi, T., Kondo, S., et al.Dopastin, an inhibitor of dopamine β-hydroxylaseJ. Antibiot. (Tokyo)25(8)497-500(1972) 2.Iinuma, H., Matsuzaki, M., Nagatsu, T., et al.Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylaseAgric. BioI. Chem.38(11)2107-2111(1974)
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