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- TNF Receptor
- T-5342126
T-5342126
A TLR4 antagonist
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥937.00750.00- +
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5mg￥3912.003130.00- +
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10mg￥6937.005550.00- +
- 货号: ajcx25072
- CAS: 956507-49-6
- 别名:
- 分子式: C25H32ClN3O3
- 分子量: 458
- 纯度: ＞98%
- 溶解度: Methyl Acetate: 10 mg/ml
- 储存: -20°C
- 库存: 现货
Background
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1 It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.2
1.Chavez, S.A., Martinko, A.J., Lau, C., et al.Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antisepticsJ. Med. Chem.54(13)4659-4669(2011) 2.Bajo, M., Montgomery, S.E., Cates, L.N., et al.Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent miceAlcohol Alcohol.51(5)541-548(2016)
