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- TNF Receptor
- SMU127
SMU127
An agonist of TLR1/2
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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500ug￥1337.001070.00- +
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1mg￥2562.002050.00- +
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5mg￥8687.006950.00- +
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- 货号: ajcx25076
- CAS: 903864-87-9
- 别名: ZINC666243
- 分子式: C16H23N3O3S
- 分子量: 337.4
- 纯度: ＞98%
- 溶解度: DMF: 1 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: slightly soluble
- 储存: -20°C
- 库存: 现货
Background
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.1 It induces NF-κB signaling in cells expressing human TLR2 (EC50 = 0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 µM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 µM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.
1.Chen, Z., Cen, X., Yang, J., et al.Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library databaseChem. Commun. (Camb.)54(81)11411-11414(2018)
