An internal standard for the quantification of oxaprozin
Oxaprozin-d5 is intended for use as an internal standard for the quantification of oxaprozin by GC- or LC-MS. Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 μM for human COX-1 and COX-2, respectively).1 It decreases acetic acid-induced writhing times and carrageenan-induced paw edema in mice when administered at doses of 100 and 70 mg/kg, respectively.2 Formulations containing oxaprozin have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.
1.Kawai, S., Nishida, S., Kato, M., et al.Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cellsEur. J. Pharmacol.347(1)87-94(1998) 2.Zhou, X.P., Zhang, M.X., Sun, W., et al.Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drugBiol. Pharm. Bull.32(12)1986-1990(2009)
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