CP94

An iron chelator

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库存: 现货

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数量
1mg

￥512.00

410.00

- +
5mg

￥2337.00

1870.00

- +
10mg

￥4100.00

3280.00

- +
25mg

￥9000.00

7200.00

- +

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货号: ajcx25096
CAS: 115900-75-9
别名: 1,2-二乙基-3-羟基吡啶-4(1H)-酮
分子式: C9H13NO2
分子量: 167.2
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: -20°C
库存: 现货

Background

CP94 is an iron chelator.¹ It enhances protoporphyrin IX photobleaching and decreases in the viability of A431 squamous epithelial carcinoma cells when used at a concentration of 150 µM in combination with photodynamic therapy (PDT) mediated by the protoporphyrin IX precursors aminolevulinic acid (ALA), methyl aminolevulinate (MAL), or hexylaminolevulinate .² CP94 (2 mg/ml in the drinking water) decreases hepatic total non-heme and ferritin-stored iron levels, as well as increases hepatic protoporphyrin levels, in mice.³ It also reduces ferrocene-induced increases in rat brain iron levels when administered at a dose of 100 mg/kg.⁴

1.Dobbin, P.S., Hider, R.C., Hall, A.D., et al.Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potentialJ. Med. Chem.36(17)2448-2458(1993) 2.Blake, E., Allen, J., and Curnow, A.The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditionsPhotodiagnosis Photodyn. Ther.10(4)575-582(2013) 3.Smith, A.G., Clothier, B., Francis, J.E., et al.Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn miceBlood89(3)1045-1051(1997) 4.Ward, R.J., Dexter, D., Florence, A., et al.Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolismBiochem. Pharmacol.49(12)1821-1826(1995)