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  • CP94
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CP94

An iron chelator

原价
¥512-9000
价格
410-7200
CP94的二维码

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  • 货号: ajcx25096
  • CAS: 115900-75-9
  • 别名: 1,2-二乙基-3-羟基吡啶-4(1H)-酮
  • 分子式: C9H13NO2
  • 分子量: 167.2
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
  • 储存: -20°C
  • 库存: 现货

Background

CP94 is an iron chelator.1 It enhances protoporphyrin IX photobleaching and decreases in the viability of A431 squamous epithelial carcinoma cells when used at a concentration of 150 µM in combination with photodynamic therapy (PDT) mediated by the protoporphyrin IX precursors aminolevulinic acid (ALA), methyl aminolevulinate (MAL), or hexylaminolevulinate .2 CP94 (2 mg/ml in the drinking water) decreases hepatic total non-heme and ferritin-stored iron levels, as well as increases hepatic protoporphyrin levels, in mice.3 It also reduces ferrocene-induced increases in rat brain iron levels when administered at a dose of 100 mg/kg.4



1.Dobbin, P.S., Hider, R.C., Hall, A.D., et al.Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potentialJ. Med. Chem.36(17)2448-2458(1993) 2.Blake, E., Allen, J., and Curnow, A.The effects of protoporphyrin IX-induced photodynamic therapy with and without iron chelation on human squamous carcinoma cells cultured under normoxic, hypoxic and hyperoxic conditionsPhotodiagnosis Photodyn. Ther.10(4)575-582(2013) 3.Smith, A.G., Clothier, B., Francis, J.E., et al.Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn miceBlood89(3)1045-1051(1997) 4.Ward, R.J., Dexter, D., Florence, A., et al.Brain iron in the ferrocene-loaded rat: its chelation and influence on dopamine metabolismBiochem. Pharmacol.49(12)1821-1826(1995)

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