Alizapride-13C-d3 (hydrochloride)

An internal standard for the quantification of alizapride

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库存: 现货

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数量
500ug

￥2037.00

1630.00

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1mg

￥3862.00

3090.00

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5mg

￥15100.00

12080.00

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货号: ajcx25118
CAS: N/A
别名:
分子式: C15[13C]H18D3N5O2·HCl
分子量: 355.9
纯度: >98%
溶解度: DMSO: soluble,Methanol: soluble,Water: soluble
储存: -20°C
库存: 现货

Background

Alizapride-¹³C-d₃ is intended for use as an internal standard for the quantification of alizapride by GC- or LC-MS. Alizapride is a dopamine D₂ receptor antagonist (K_i = 66-340 nM in radioligand binding assays).¹ It is selective for dopamine D₂ over α₁-, α₂-, and β-adrenergic receptors (IC₅₀s = >10 µM for all). It reduces decreases in gastrointestinal transit induced by dopamine , apomorphine, or bromocriptine in rats when administered at a dose of 5 mg/kg.² Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.

1.Chivers, J.K., Gommeren, W., Leysen, J.E., et al.Comparison of the in-vitro receptor selectivity of substituted benzamide drugs for brain neurotransmitter receptorsJ. Pharm. Pharmacol.40(6)415-421(1988) 2.Dhasmana, K.M., Villalón, C.M., Zhu, Y.N., et al.The role of dopamine (D2), α and β-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the ratPharmacol. Res.27(4)335-347(1993)