An internal standard for the quantification of 1-palmitoyl lysophosphatidic acid
1-Palmitoyl-d9 lysophosphatidic acid (1-palmitoyl-d9 LPA) is intended for use as an internal standard for the quantification of 1-palmitoyl LPA by GC- or LC-MS. 1-Palmitoyl LPA is an analog of LPA that contains palmitic acid at the sn-1 position. It induces reporter gene expression in PC12 cells expressing human lysophosphatidic acid receptor 4 (LPA4) when used at concentrations ranging from 0.01 to 10 µM.1 1-Palmitoyl LPA (12-300 µM) induces aggregation of isolated human platelets, an effect that can be reversed by prostaglandin E1 , theophylline , or EDTA.2 It also binds to calcium and magnesium and enhances the activity of ampicillin , piperacillin , and ceftazidime against P. aeruginosa isolates from patients with cystic fibrosis.3
1.Noguchi, K., Ishii, S., and Shimizu, T.Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg familyJ. Biol. Chem.278(28)25600-25606(2003) 2.Gerrard, J.M., Kindom, S.E., Peterson, D.A., et al.Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium fluxAm. J. Pathol.96(2)423-438(1979) 3.Krogfelt, K.A., Utley, M., Krivan, H.C., et al.Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosaJ. Antimicrob. Chemother.46(3)377-384(2000)
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