A guanosine analog with diverse biological activities
Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties.1,2 It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively).1 It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.2
1.Saito, Y., Nakamura, M., Ohno, T., et al.Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agentsJ. Antibiot. (Tokyo)53(3)309-313(2000) 2.Shimada, N., Yagisawa, N., Naganawa, H., et al.Oxanosine, a novel nucleoside from actinomycetesJ. Antibiot. (Tokyo)34(9)1216-1218(1981)
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