C82
An Mtb CdnP inhibitor
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包装价格促销价数量
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1mg￥937.00750.00- +
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5mg￥3687.002950.00- +
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10mg￥6462.005170.00- +
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- 货号: ajcx25136
- CAS: 691862-35-8
- 别名:
- 分子式: C17H17N3O3S
- 分子量: 343.4
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
- 储存: -20°C
- 库存: 现货
Background
C82 is an inhibitor of M. tuberculosis (Mtb) cyclic dinucleotide phosphodiesterase (CdnP; IC50 = 17.5 µM), the enzyme that catalyzes the hydrolysis of cyclic di-AMP to adenosine 5’-monophosphate .1 It is selective for Mtb CdnP over the additional bacterial CDN phosphodiesterases (PDEs) Yybt, RocR, and group B streptococcus (GBS) CdnP, the mammalian CDN PDE ENPP1, and the viral CDN PDE poxin at 200 µM.
1.Karanja, C.W., Yeboah, K.S., and Sintim, H.O.Identification of a Mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase inhibitorACS Infect. Dis.7(2)309-317(2021)
