A monolignol with anti-inflammatory and antinociceptive activities
Sinapyl alcohol is a monolignol and an aglycone form of syringin that has been found in Populus alba and has anti-inflammatory and antinociceptive activities.1,2 It is a precursor in the biosynthesis of lignin.1 Sinapyl alcohol (50, 100, and 200 µM) reduces LPS-induced production of nitrite, prostaglandin E2 , and TNF-α in RAW 264.7 cells.2 Sinapyl alcohol (20 and 30 mg/kg) inhibits acetic acid-induced writhing and increases the latency to paw licking in the hot plate test in mice.
1.Shigeto, J., Ueda, Y., Sasaki, S., et al.Enzymatic activities for lignin monomer intermediates highlight the biosynthetic pathway of syringyl monomers in Robinia pseudoacaciaJ. Plant Res.130(1)203-210(2017) 2.Choi, J., Shin, K.-M., Park, H.-J., et al.Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringinPlanta Med.70(11)1027-1032(2004)
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