Phenylbutazone-d9
An internal standard for the quantification of phenylbutazone
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包装价格促销价数量
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500ug￥2037.001630.00- +
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1mg￥3262.002610.00- +
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5mg￥11187.008950.00- +
- 货号: ajcx25234
- CAS: 1189479-75-1
- 别名: 保泰松 d9
- 分子式: C19H11D9N2O2
- 分子量: 317.4
- 纯度: ＞98%
- 溶解度: Methanol: soluble
- 储存: -20°C
- 库存: 现货
Background
Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide).1 It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2 Formulations containing phenylbutazone have been used in the treatment of lameness in horses.
1.Reed, G.A., Griffin, I.O., and Eling, T.E.Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolismMol. Pharmacol.27(1)109-114(1985) 2.de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al.In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitisVet. J.201(1)51-56(2014)
