N’-Nitrosonornicotine

An N-nitrosamine and a carcinogen

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50mg

￥1712.00

1370.00

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100mg

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2610.00

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货号: ajcx25302
CAS: 80508-23-2
别名: N-亚硝基降烟碱(NNN)
分子式: C9H11N3O
分子量: 177.2
纯度: >98%
溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.¹ It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.²

1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N’-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)