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- RSV (Respiratory syncytial virus)
- GS-441524 tris-isobutyryl ester
GS-441524 tris-isobutyryl ester
An orally bioavailable prodrug form of GS-443902
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包装价格促销价数量
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500ug￥1212.00970.00- +
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1mg￥2187.001750.00- +
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- 货号: ajcx25306
- CAS: 2563617-99-0
- 别名: GS-441524 tris-isobutyryl ester
- 分子式: C24H31N5O7
- 分子量: 501.5
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
- 储存: -20°C
- 库存: 现货
Background
GS-441524 tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1 It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50 value of 0.26 µM.
1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021)
