Visnagin
A furanochromone with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
100mg￥587.00470.00- +
-
500mg￥1300.001040.00- +
-
1g￥2037.001630.00- +
- 货号: ajcx25312
- CAS: 82-57-5
- 别名: 齿阿米素
- 分子式: C13H10O4
- 分子量: 230.2
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 5 mg/ml,Ethanol: 1 mg/ml
- 储存: Store at -20°C,protect from light
- 库存: 现货
Background
Visnagin is a polyketide synthase-derived furanochromone originally isolated from A. visnaga that has diverse biological activities.1,2,3,4,5 It inhibits the germination and growth of ryegrass (IC50s = 502 and 214 µM, respectively).2 Visnagin (100 µg/ml) is cytotoxic to, and induces apoptosis in, HT-144 melanoma cells.3 It reduces LPS-stimulated increases in the secretion of TNF-α, IL-1β, and IFN-γ in BV-2 microglial cells when used at concentrations of 50 and 100 µM.4 Visnagin (25 mg/kg) protects against cardiomyopathy induced by doxorubicin in mice.5
1.Abe, I.Engineering of plant polyketide biosynthesisChem. Pharm. Bull. (Tokyo)56(11)1505-1514(2008) 2.Travaini, M.L., Sosa, G.M., Ceccarelli, E.A., et al.Khellin and visnagin, furanochromones from Ammi visnaga (L.) Lam., as potential bioherbicidesJ. Agric. Food Chem.64(50)9475-9487(2016) 3.Aydo?mu?-?ztürk, F., Jahan, H., Beyazit, N., et al.The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144Mol. Biol. Rep.46(2)1709-1714(2019) 4.Lee, J.-K., Jung, J.-S., Park, S.-H., et al.Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cellsArch. Pharm. Res.33(11)1843-1850(2010) 5.Liu, Y., Asnani, A., Zou, L., et al.Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenaseSci. Transl. Med.6(266)266ra170(2014)
