O-desmethyl Brinzolamide (hydrochloride)

An active metabolite of brinzolamide

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库存: 现货

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1mg

￥937.00

750.00

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5mg

￥3912.00

3130.00

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10mg

￥7387.00

5910.00

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Background

O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .^1,2 It inhibits CAII and CAIV (IC₅₀s = 0.136 and 165 nM, respectively).¹

1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tandem mass spectrometry method for determining carbonic anhydrase inhibitors and their metabolites in urine and hairDrug Test Anal.13(8)1552-1560(2021)