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  • O-desmethyl Brinzolamide (hydrochloride)
O-desmethyl Brinzolamide (hydrochloride)的可视化放大

O-desmethyl Brinzolamide (hydrochloride)

An active metabolite of brinzolamide

原价
¥937-7387
价格
750-5910
O-desmethyl Brinzolamide (hydrochloride)的二维码

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  • 货号: ajcx25390
  • CAS: N/A
  • 别名:
  • 分子式: C11H19N3O5S3·HCl
  • 分子量: 405.9
  • 纯度: >98%
  • 溶解度: DMSO: soluble
  • 储存: -20°C
  • 库存: 现货

Background

O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2 It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1



1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tandem mass spectrometry method for determining carbonic anhydrase inhibitors and their metabolites in urine and hairDrug Test Anal.13(8)1552-1560(2021)

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