Acetylthiocholine (iodide)

A substrate for AChE and an agonist of α4β2-subunit containing nAChRs

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5g

￥1150.00

920.00

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10g

￥2037.00

1630.00

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25g

￥4500.00

3600.00

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50g

￥7900.00

6320.00

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货号: ajcx25416
CAS: 1866-15-5
别名: 碘代硫代乙酰胆碱
分子式: C7H16NOS·I
分子量: 289.2
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: -20°C
库存: 现货

Background

Acetylthiocholine is a substrate for acetylcholinesterase (AChE) and an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs).^1,2 It binds to α4β2 subunit-containing nAChRs in SH-EP1 cells (IC₅₀ = 7.1 µM for the human receptor) and induces rubidium efflux in an agonist-induced rubidium efflux assay (EC₅₀ = 100 µM).² Acetylthiocholine has been used as part of a thiocholine sensor for the detection of pesticides in complex sample types, such as soil, groundwater, and spinach.¹

1.Chen, L., Tian, X., Li, Y., et al.Broad-spectrum pesticide screening by multiple cholinesterases and thiocholine sensors assembled high-throughput optical array systemJ. Hazard. Mater.402123830(2021) 2.Eaton, J.B., Peng, J.-H., Schroeder, K.M., et al.Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cellsMol. Pharmacol.64(6)1283-1294(2003)