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- CAY10787
CAY10787
An oxysterol and a negative allosteric modulator of GABAA receptors
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1837.001470.00- +
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5mg￥7787.006230.00- +
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10mg￥14475.0011580.00- +
- 货号: ajcx25420
- CAS: 567-72-6
- 别名: Δ3,5-Cholestadien-7-one, CSD, NSC 18180, NSC 134914
- 分子式: C27H42O
- 分子量: 382.6
- 纯度: ＞98%
- 溶解度: Chloroform: 10 mg/ml
- 储存: -20°C
- 库存: 现货
Background
CAY10787 is an oxysterol and a negative allosteric modulator of GABAA receptors.1,2 It reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors (IC50s = 1.5 and 1 µM, respectively).2 CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons. In vivo, CAY10787 (2, 10, and 50 mg/kg) increases latency to nocifensive behaviors in the hot plate test in mice.
1.Hahn, M., Tang, M., and Subbiah, M.T.Cholest-3,5-dien-7-one formation in peroxidized human plasma as an indicator of lipoprotein cholesterol peroxidation potentialBiochim. Biophys. Acta1255(3)341-343(1995) 2.Niu, C., Leavitt, L.S., Lin, Z., et al.Neuroactive type-A γ-aminobutyric acid receptor allosteric modulator steroids from the hypobranchial gland of marine mollusk, Conus geographusJ. Med. Chem.64(10)7033-7043(2021)
