Ganodermanontriol
A triterpene with diverse biological activities
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包装价格促销价数量
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1mg￥4075.003260.00- +
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5mg￥36425.0029140.00- +
- 货号: ajcx25424
- CAS: 106518-63-2
- 别名: 灵芝马酮
- 分子式: C30H48O4
- 分子量: 472.7
- 纯度: ＞98%
- 溶解度: Chloroform: soluble
- 储存: -20°C
- 库存: 现货
Background
Ganodermanontriol is a triterpene that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits the activity of HIV-1 protease (IC50 = 70 µM), as well as reduces the activity of 5α-reductase by 32% when used at a concentration of 667 µM.1,2 Ganodermanontriol (25 and 50 µM) inhibits proliferation, colony formation, invasion, and migration of MDA-MB-231 human breast cancer cells.3 It reduces hepatocyte necrosis and increases in hepatic TNF-α and IL-6 levels in a mouse model of LPS/D-galactosamine-induced acute liver injury when administered at a dose of 5 mg/kg.4
1.Min, B.-S., Nakamura, N., Miyashiro, H., et al.Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 proteaseChem. Pharm. Bull.46(10)1607-1612(1998) 2.Liu, J., Kurashiki, K., Shimizu, K., et al.Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidumBioorg. Med. Chem.14(24)8654-8660(2006) 3.Jiang, J., Jedinak, A., and Silva, D.Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPABiochem. Biophys. Res. Commun.415(2)325-329(2011) 4.Hu, Z., Du, R., Xiu, L., et al.Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injuryCytokine127154917(2020)
