- 首页
- Janus kinase (JAK)
- Methyl Diethyldithiocarbamate
Methyl Diethyldithiocarbamate
An active metabolite of disulfiram
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
25mg￥975.00780.00- +
-
50mg￥1837.001470.00- +
-
100mg￥3112.002490.00- +
-
250mg￥5787.004630.00- +
- 货号: ajcx25448
- CAS: 686-07-7
- 别名: S-甲基N,N二乙基二硫代氨基甲酸
- 分子式: C6H13NS2
- 分子量: 163.3
- 纯度: ＞98%
- 溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
- 储存: -20°C
- 库存: 现货
Background
Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1 It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2 Methyl diethyldithiocarbamate inhibits liver low Km aldehyde dehydrogenase (ALDH) in rats (ID50 = 15.5 mg/kg).1 It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg.
1.Hart, B.W., Yourick, J.J., and Faiman, M.D.S-methyl-N,N-diethylthiolcarbamate: A disulfiram metabolite and potent rat liver mitochondrial low Km aldehyde dehydrogenase inhibitorAlcohol7(2)165-169(1990) 2.Gessner, T., and Jakubowski, M.Diethyldithiocarbamic acid methyl ester. A metabolite of disulfiramBiochem. Pharmacol.21(2)219-230(1972)
