A sesquiterpene with antimicrobial and anticancer activities
(+)-δ-Cadinene is a sesquiterpene that has been found in upland cotton (G. hirsutum) and has antibacterial, insecticidal, and anticancer activities.1,2,3,4 It is active against S. pneumoniae (MIC = 31.25 µg/ml) and induces mortality in A. stephensi, A. aegypti, and C. quinquefasciatus third instar larvae (LC50s = 8.23, 9.03, and 9.86 µg/ml, respectively).2,3 (+)-δ-Cadinene (10, 50, and 100 µM) induces apoptosis in and inhibits proliferation of OVCAR-3 human ovarian cancer cells.4
1.Davis, G.D., and Essenberg, M.(+)-δ-Cadinene is a product of sesquiterpene cyclase activity in cottonPhytochemistry39(3)553-567(1995) 2.Pérez-López, A., Cirio, A.T., Rivas-Galindo, V.M., et al.Activity against Streptococcus pneumoniae of the essential oil and δ-cadinene isolated from Schinus molle fruitJ. Essent. Oil Res.23(5)25-28(2011) 3.Govindarajan, M., Rajeswary, M., and Benelli, G.δ-Cadinene, calarene and δ-4-carene from Kadsura heteroclita essential oil as novel larvicides against malaria, dengue and filariasis mosquitoesComb. Chem. High Throughput Screen.19(7)565-571(2016) 4.Hui, L.-M., Zhao, G.-D., and Zhao, J.-J.δ-Cadinene inhibits the growth of ovarian cancer cells via caspase-dependent apoptosis and cell cycle arrestInt. J. Clin. Exp. Pathol.8(6)6046-6056(2015)
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