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  • Carboplatin-d4
Carboplatin-d4的可视化放大

Carboplatin-d4

卡铂-d4 (NSC 241240-d4) 是氘标记的卡铂。 Carboplatin (NSC 241240) 是一种 DNA 合成抑制剂,可与 DNA 结合,抑制复制和转录并诱导细胞死亡。 Carboplatin (NSC 241240) 是 CDDP 的衍生物,是一种有效的抗癌剂。

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  • 货号: ajcx25534
  • CAS: N/A
  • 别名: NSC 241240-d4
  • 分子式: C6H8D4N2O4Pt
  • 分子量: 375.3
  • 纯度: >98%
  • 溶解度: Methanol: slightly soluble,Water: slightly soluble
  • 储存: -20°C
  • 库存: 现货

Background

Carboplatin-d4 is intended for use as an internal standard for the quantification of carboplatin by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.1 It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).2,3 Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.).4 Formulations containing carboplatin have been used in the treatment of ovarian cancer.



1.Micetich, K.C., Barnes, D., and Erickson, L.C.A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cellsCancer Res.45(9)4043-4047(1985) 2.Groen, H.J., Sleijfer, S., Meijer, C., et al.Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell linesBr. J. Cancer72(6)1406-1411(1995) 3.Al-Eisawi, Z., Beale, P., Chan, C., et al.Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour modelsJ. Ovarian Res.6(1)78(2013) 4.Kelland, L.R., Abel, G., McKeage, M.J., et al.Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): An orally active platinum drugCancer Res.53(11)2581-2586(1993)

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