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  • Dolutegravir O-β-D-Glucuronide
Dolutegravir O-β-D-Glucuronide的可视化放大

Dolutegravir O-β-D-Glucuronide

A metabolite of dolutegravir

原价
¥10237-10237
价格
8190-8190
Dolutegravir O-β-D-Glucuronide的二维码

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  • 库存: 现货
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  • 货号: ajcx25540
  • CAS: 1485692-21-4
  • 别名: Dolutegravir Glucuronide, DTG Glucuronide
  • 分子式: C26H27F2N3O11
  • 分子量: 595.5
  • 纯度: >98%
  • 溶解度: Water: slightly, sonicated
  • 储存: -20°C
  • 库存: 现货

Background

Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1 It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1 in vivo but is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1



1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544(2019) 2.Reese, M.J., Savina, P.M., Generaux, G.T., et al.In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitorDrug Metab. Dispos.41(2)353-361(2013)

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