Dolutegravir O-β-D-Glucuronide

A metabolite of dolutegravir

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库存: 现货

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2.5mg

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货号: ajcx25540
CAS: 1485692-21-4
别名: Dolutegravir Glucuronide, DTG Glucuronide
分子式: C26H27F2N3O11
分子量: 595.5
纯度: >98%
溶解度: Water: slightly, sonicated
储存: -20°C
库存: 现货

Background

Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .¹ It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1 in vivo but is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.^2,1

1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544(2019) 2.Reese, M.J., Savina, P.M., Generaux, G.T., et al.In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitorDrug Metab. Dispos.41(2)353-361(2013)