H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)

An RGD-containing tetrapeptide

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库存: 现货

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10mg

￥1012.00

810.00

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50mg

￥4525.00

3620.00

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100mg

￥8050.00

6440.00

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货号: ajcx25572
CAS: N/A
别名: H-RGDC-OH
分子式: C15H27N7O7S·XCF3COOH
分子量: 449.5
纯度: >98%
溶解度: Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: -20°C
库存: 现货

Background

H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.¹ It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC₅₀ values of 320 and 35 µM, respectively.² Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.³ H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection efficiency.⁴

1.Park, H.S., Kim, C., and Kang, Y.K.Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to plateletsBiopolymers63(5)298-313(2002) 2.Tranqui, L., Andrieux, A., Hudry-Clergeon, G., et al.Differential structural requirements for fibrinogen binding to platelets and to endothelial cellsJ. Cell Biol.108(6)2519-2527(1989) 3.Ferris, D.M., Moodie, G.D., Dimond, P.M., et al.RGD-coated titanium implants stimulate increased bone formation in vivoBiomaterials20(23-24)2323-2331(1999) 4.Kunath, K., Merdan, T., Hegener, O., et al.Integrin targeting using RGD-PEI conjugates for in vitro gene transferJ. Gene Med.5(7)588-599(2003)