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- PKD (Protein kinase D)
- Chroman 1 (hydrochloride hydrate)
Chroman 1 (hydrochloride hydrate)
A ROCK2 inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥937.00750.00- +
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5mg￥3912.003130.00- +
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10mg￥6462.005170.00- +
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- 货号: ajcx25628
- CAS: N/A
- 别名: (S)-Chroman 1
- 分子式: C24H28N4O4·2HCl [XH2O]
- 分子量: 527.4
- 纯度: ＞98%
- 溶解度: DMSO: 100 mM,Water: 5 mM
- 储存: -20°C
- 库存: 现货
Background
Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = <1 nM).1 It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50 = <4 nM).
1.Chen, Y.T., Vojkovsky, T., Fang, X., et al.Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitorsMed. Chem. Commun.2(1)73-75(2011)
