An internal standard for the quantification of berberine
Berberine-d6 is intended for use as an internal standard for the quantification of berberine by GC- or LC-MS. Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.1,2,3,4,5 It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae, respectively, in the exponential growth phase when used at a concentration of 50 µg/ml.2 Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).3 It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.4 Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.5
1.Malhotra, S., Taneja, S.C., and Dhar, K.L.Minor alkaloid from Coscinium fenestratumPhytochem.28(7)1998-1999(1989) 2.Pasqual, M.S., Lauer, C.P., Moyna, P., et al.Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organismsMutat. Res.286(2)243-252(1993) 3.Iwasa, K., Kamigauchi, M., Ueki, M., et al.Antibacterial activity and structure-activity relationships of berberine analogsEur. J. Med. Chem.31(6)469-478(1996) 4.Chen, C.C., Hung, T.H., Lee, C.Y., et al.Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injuryPLoS One9(12)e115694(2014) 5.Kong, W., Wei, J., Abidi, P., et al.Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsNat. Med.10(12)1344-1351(2004)
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