Metanephrine-d3 (hydrochloride)

An internal standard for the quantification of metanephrine

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库存: 现货

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500ug

￥1837.00

1470.00

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1mg

￥3500.00

2800.00

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5mg

￥11887.00

9510.00

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货号: ajcx25802
CAS: 1215507-88-2
别名: DL-Metanephrine-d3
分子式: C10H12D3NO3·HCl
分子量: 236.7
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 15 mg/ml
储存: -20°C
库存: 现货

Background

Metanephrine-d₃ is intended for use as an internal standard for the quantification of metanephrine by GC- or LC-MS. Metanephrine is an inactive metabolite of epinephrine .¹ It is formed from epinephrine by catechol-O-methyl transferase (COMT).² Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.^3,4

1.Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E.Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclaseBiochem. Pharmacol.27(10)1445-1454(1978) 2.Kopin, I.J., Axelrod, J., and Gordon, E.The metabolic fate of H3-epinephrine and C14-metanephrine in the ratJ. Biol. Chem.236(7)2109-2136(1961) 3.Wolthers, B.G., Kema, I.P., Volmer, M., et al.Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometryClin. Chem.43(1)114-120(1997) 4.Goldstein, D.S., Eisenhofer, G., and Kopin, I.J.Sources and significance of plasma levels of catechols and their metabolites in humansJ. Pharm. Exp. Ther.305(3)800-811(2003)